6dwm: Difference between revisions

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'''Unreleased structure'''


The entry 6dwm is ON HOLD  until Paper Publication
==Structure of Human Cytochrome P450 1A1 with Bergamottin==
 
<StructureSection load='6dwm' size='340' side='right' caption='[[6dwm]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
Authors: Bart, A.G., Scott, E.E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6dwm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DWM FirstGlance]. <br>
Description: Structure of Human Cytochrome P450 1A1 with Bergamottin
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HJJ:4-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g][1]benzopyran-7-one'>HJJ</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
[[Category: Scott, E.E]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dwm OCA], [http://pdbe.org/6dwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dwm RCSB], [http://www.ebi.ac.uk/pdbsum/6dwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dwm ProSAT]</span></td></tr>
[[Category: Bart, A.G]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CP1A1_HUMAN CP1A1_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
__TOC__
</StructureSection>
[[Category: Unspecific monooxygenase]]
[[Category: Bart, A G]]
[[Category: Scott, E E]]
[[Category: Ligand]]
[[Category: Oxidoreductase]]

Revision as of 10:48, 3 October 2018

Structure of Human Cytochrome P450 1A1 with BergamottinStructure of Human Cytochrome P450 1A1 with Bergamottin

Structural highlights

6dwm is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Activity:Unspecific monooxygenase, with EC number 1.14.14.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CP1A1_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6dwm, resolution 2.85Å

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