2rkq: Difference between revisions
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==Crystal structure of drosophila peptidoglycan recognition protein SD (PGRP-SD)== | ==Crystal structure of drosophila peptidoglycan recognition protein SD (PGRP-SD)== | ||
<StructureSection load='2rkq' size='340' side='right' caption='[[2rkq]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='2rkq' size='340' side='right'caption='[[2rkq]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2rkq]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2rkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RKQ FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PGRP-SD ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PGRP-SD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rkq OCA], [https://pdbe.org/2rkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rkq RCSB], [https://www.ebi.ac.uk/pdbsum/2rkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rkq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/PGPSD_DROME PGPSD_DROME]] Peptidoglycan-recognition protein that plays a key role in innate immnunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway. Has no activity against on Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SA in Gram-positive bacteria recognition. May act by activating the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Recognizes S.aureus PGN.<ref>PMID:15448690</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Drome]] | [[Category: Drome]] | ||
[[Category: Large Structures]] | |||
[[Category: Kellenberger, C]] | [[Category: Kellenberger, C]] | ||
[[Category: Leone, P]] | [[Category: Leone, P]] |