6hij: Difference between revisions

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-'''Unreleased structure'''
-The entry 6hij is ON HOLD
+==Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and PE lipids docked==
+<StructureSection load='6hij' size='340' side='right' caption='[[6hij]], [[Resolution|resolution]] 3.56&Aring;' scene=''>
-Authors: Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Taylor, N.M.I., Bause, M., Bauer, S., Bartholomaeus, R., Stahlberg, H., Bernhardt, G., Koenig, B., Buschauer, A., Altmann, K.H., Locher, K.P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6hij]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HIJ FirstGlance]. <br>
-Description: Structure of an inhibitor-bound ABC transporter
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BWQ:~{tert}-butyl+3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate'>BWQ</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ffc|6ffc]]</td></tr>
-[[Category: Locher, K.P]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hij OCA], [http://pdbe.org/6hij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hij RCSB], [http://www.ebi.ac.uk/pdbsum/6hij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hij ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ABCG2_HUMAN ABCG2_HUMAN]] High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.<ref>PMID:12958161</ref> <ref>PMID:20705604</ref> <ref>PMID:22132962</ref> <ref>PMID:23189181</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Altmann, K H]]
+[[Category: Bartholomaeus, R]]
+[[Category: Bauer, S]]
+[[Category: Bause, M]]
 [[Category: Bernhardt, G]]
-[[Category: Jackson, S.M]]
+[[Category: Buschauer, A]]
-[[Category: Bause, M]]
+[[Category: Jackson, S M]]
+[[Category: Koenig, B]]
 [[Category: Kowal, J]]
-[[Category: Altmann, K.H]]
+[[Category: Locher, K P]]
-[[Category: Bauer, S]]
+[[Category: Manolaridis, I]]
-[[Category: Koenig, B]]
+[[Category: Stahlberg, H]]
-[[Category: Bartholomaeus, R]]
+[[Category: Taylor, N M.I]]
 [[Category: Zechner, M]]
-[[Category: Stahlberg, H]]
+[[Category: Abc transporter]]
-[[Category: Buschauer, A]]
+[[Category: Transport protein]]
-[[Category: Taylor, N.M.I]]
-[[Category: Manolaridis, I]]