2pd7: Difference between revisions

Revision as of 12:53, 4 May 2008

2.0 Angstrom Crystal Structure of the Fungal Blue-Light Photoreceptor Vivid

OverviewOverview

The Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates gating of the circadian clock. Crystal structures of dark-state and light-state Vivid reveal a light, oxygen, or voltage Per-Arnt-Sim domain with an unusual N-terminal cap region and a loop insertion that accommodates the flavin cofactor. Photoinduced formation of a cystein-flavin adduct drives flavin protonation to induce an N-terminal conformational change. A cysteine-to-serine substitution remote from the flavin adenine dinucleotide binding site decouples conformational switching from the flavin photocycle and prevents Vivid from sending signals in Neurospora. Key elements of this activation mechanism are conserved by other photosensors such as White Collar-1, ZEITLUPE, ENVOY, and flavin-binding, kelch repeat, F-BOX 1 (FKF1).

About this StructureAbout this Structure

2PD7 is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

ReferenceReference

Conformational switching in the fungal light sensor Vivid., Zoltowski BD, Schwerdtfeger C, Widom J, Loros JJ, Bilwes AM, Dunlap JC, Crane BR, Science. 2007 May 18;316(5827):1054-7. PMID:17510367 Page seeded by OCA on Sun May 4 12:53:44 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2pd7.jpg|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_2pd7", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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-|GENE= vvd, G17A4.050 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Neurospora crassa])
+-->
-|DOMAIN=
+{{STRUCTURE_2pd7|  PDB=2pd7  |  SCENE=  }}
-|RELATEDENTRY=[[2pd8|2PD8]], [[2pdr|2PDR]], [[2pdt|2PDT]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pd7 OCA], [http://www.ebi.ac.uk/pdbsum/2pd7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pd7 RCSB]</span>
-}}
 '''2.0 Angstrom Crystal Structure of the Fungal Blue-Light Photoreceptor Vivid'''
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 [[Category: Crane, B R.]]
 [[Category: Zoltowski, B D.]]
-[[Category: circadian clock]]
+[[Category: Circadian clock]]
-[[Category: flavin]]
+[[Category: Flavin]]
-[[Category: lov domain]]
+[[Category: Lov domain]]
-[[Category: photoreceptor]]
+[[Category: Photoreceptor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:53:44 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:34:28 2008''