P53: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 43: | Line 43: | ||
There is a Zn-binding motif on p53. The p53 Zn atom is coordinated by residues <scene name='26/26327/B_chain_and_dna/12'>C176, H179, C238, and C242</scene> that are located on two loops, respectively. It is conceivable that the zinc plays a role in stabilizing the two loops through | There is a Zn-binding motif on p53. The p53 Zn atom is coordinated by residues <scene name='26/26327/B_chain_and_dna/12'>C176, H179, C238, and C242</scene> that are located on two loops, respectively. It is conceivable that the zinc plays a role in stabilizing the two loops through | ||
coordination. The Zn has been represented as a magenta sphere, and R248 in space filling, in the scene at the right. | coordination. The Zn has been represented as a magenta sphere, and R248 in space filling, in the scene at the right. | ||
==3D structures of p53== | |||
[[P53 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
| Line 79: | Line 83: | ||
**[[4xr8]] - h-p53 DBD + E6 + E6AP<br /> | **[[4xr8]] - h-p53 DBD + E6 + E6AP<br /> | ||
**[[4qo1]] - h-p53 DBD + nanobody<br /> | **[[4qo1]] - h-p53 DBD + nanobody<br /> | ||
**[[6rz3]] - h-p53 DBD + IASPP<br /> | |||
* p53 transactivation domain (residues 15-29) | * p53 transactivation domain (residues 15-29) | ||
| Line 96: | Line 101: | ||
** [[4mzr]], [[3q01]] – h-p53 + DNA<br /> | ** [[4mzr]], [[3q01]] – h-p53 + DNA<br /> | ||
**[[5xzc]] – h-p53 + P300 – Cryo EM<br /> | |||
}} | }} | ||