6dra: Difference between revisions
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==Low IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor== | ==Low IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor== | ||
<StructureSection load='6dra' size='340' side='right' caption='[[6dra]], [[Resolution|resolution]] 3.96Å' scene=''> | <StructureSection load='6dra' size='340' side='right'caption='[[6dra]], [[Resolution|resolution]] 3.96Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6dra]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRA FirstGlance]. <br> | <table><tr><td colspan='2'>[[6dra]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRA FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dra OCA], [http://pdbe.org/6dra PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dra RCSB], [http://www.ebi.ac.uk/pdbsum/6dra PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dra ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dra OCA], [http://pdbe.org/6dra PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dra RCSB], [http://www.ebi.ac.uk/pdbsum/6dra PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dra ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/ITPR3_HUMAN ITPR3_HUMAN]] Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. | [[http://www.uniprot.org/uniprot/ITPR3_HUMAN ITPR3_HUMAN]] Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Hite, R K]] | [[Category: Hite, R K]] | ||
[[Category: Paknejad, N]] | [[Category: Paknejad, N]] | ||
Revision as of 20:21, 20 November 2019
Low IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptorLow IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor
Structural highlights
Function[ITPR3_HUMAN] Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Publication Abstract from PubMedInositol trisphosphate receptors (IP3Rs) are ubiquitous Ca(2+)-permeable channels that mediate release of Ca(2+) from the endoplasmic reticulum, thereby regulating numerous processes including cell division, cell death, differentiation and fertilization. IP3Rs are jointly activated by inositol trisphosphate (IP3) and their permeant ion, Ca(2+). At high concentrations, however, Ca(2+) inhibits activity, ensuring precise spatiotemporal control over intracellular Ca(2+). Despite extensive characterization of IP3R, the mechanisms through which these molecules control channel gating have remained elusive. Here, we present structures of full-length human type 3 IP3Rs in ligand-bound and ligand-free states. Multiple IP3-bound structures demonstrate that the large cytoplasmic domain provides a platform for propagation of long-range conformational changes to the ion-conduction gate. Structures in the presence of Ca(2+) reveal two Ca(2+)-binding sites that induce the disruption of numerous interactions between subunits, thereby inhibiting IP3R. These structures thus provide a mechanistic basis for beginning to understand the regulation of IP3R. Structural basis for the regulation of inositol trisphosphate receptors by Ca(2+) and IP3.,Paknejad N, Hite RK Nat Struct Mol Biol. 2018 Jul 16. pii: 10.1038/s41594-018-0089-6. doi:, 10.1038/s41594-018-0089-6. PMID:30013099[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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