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==Crystal structure of Ebola virus VP30 C-terminus/RBBP6 peptide complex== | |||
<StructureSection load='6e5x' size='340' side='right' caption='[[6e5x]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6e5x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E5X FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5x OCA], [http://pdbe.org/6e5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e5x RCSB], [http://www.ebi.ac.uk/pdbsum/6e5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5x ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/VP30_EBOZ5 VP30_EBOZ5]] Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity). [[http://www.uniprot.org/uniprot/RBBP6_HUMAN RBBP6_HUMAN]] E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Amarasinghe, G K]] | |||
[[Category: Leung, D W]] | |||
[[Category: Liu, D]] | |||
[[Category: Small, G I]] | |||
[[Category: Viral protein]] | |||
Revision as of 09:45, 12 December 2018
Crystal structure of Ebola virus VP30 C-terminus/RBBP6 peptide complexCrystal structure of Ebola virus VP30 C-terminus/RBBP6 peptide complex
Structural highlights
Function[VP30_EBOZ5] Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity). [RBBP6_HUMAN] E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. |
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