2miz: Difference between revisions
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==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain== | ==Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain== | ||
<StructureSection load='2miz' size='340' side='right' caption='[[2miz]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | <StructureSection load='2miz' size='340' side='right'caption='[[2miz]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2miz]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2miz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Muhvk Muhvk]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIZ FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">m04 ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">m04 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=69156 MUHVK])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2miz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miz OCA], [https://pdbe.org/2miz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2miz RCSB], [https://www.ebi.ac.uk/pdbsum/2miz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2miz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Muhvk]] | [[Category: Muhvk]] | ||
[[Category: Bax, A]] | [[Category: Bax, A]] | ||
Revision as of 18:15, 2 June 2021
Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domainStructure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain
Structural highlights
Publication Abstract from PubMedImmunoevasins are key proteins used by viruses to subvert host immune responses. Determining their high-resolution structures is key to understanding virus-host interactions toward the design of vaccines and other antiviral therapies. Mouse cytomegalovirus encodes a unique set of immunoevasins, the m02-m06 family, that modulates major histocompatibility complex class I (MHC-I) antigen presentation to CD8+ T cells and natural killer cells. Notwithstanding the large number of genetic and functional studies, the structural biology of immunoevasins remains incompletely understood, largely because of crystallization bottlenecks. Here we implement a technology using sparse nuclear magnetic resonance data and integrative Rosetta modeling to determine the structure of the m04/gp34 immunoevasin extracellular domain. The structure reveals a beta fold that is representative of the m02-m06 family of viral proteins, several of which are known to bind MHC-I molecules and interfere with antigen presentation, suggesting its role as a diversified immune regulation module. The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family.,Sgourakis NG, Natarajan K, Ying J, Vogeli B, Boyd LF, Margulies DH, Bax A Structure. 2014 Sep 2;22(9):1263-73. doi: 10.1016/j.str.2014.05.018. Epub 2014, Aug 7. PMID:25126960[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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