2m7g: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structure of the Type IVa Major Pilin from the Electrically Conductive Bacterial Nanowires of Geobacter sulfurreducens== | ==Structure of the Type IVa Major Pilin from the Electrically Conductive Bacterial Nanowires of Geobacter sulfurreducens== | ||
<StructureSection load='2m7g' size='340' side='right' caption='[[2m7g]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''> | <StructureSection load='2m7g' size='340' side='right'caption='[[2m7g]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2m7g]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2m7g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geosk Geosk]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M7G FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KN400_1523, pila, pilA-N ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KN400_1523, pila, pilA-N ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=663917 GEOSK])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7g OCA], [https://pdbe.org/2m7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m7g RCSB], [https://www.ebi.ac.uk/pdbsum/2m7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 16: | Line 16: | ||
</div> | </div> | ||
<div class="pdbe-citations 2m7g" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2m7g" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 25: | Line 21: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Geosk]] | [[Category: Geosk]] | ||
[[Category: Large Structures]] | |||
[[Category: Mueller, K T]] | [[Category: Mueller, K T]] | ||
[[Category: Reardon, P N]] | [[Category: Reardon, P N]] | ||
Revision as of 14:01, 19 May 2021
Structure of the Type IVa Major Pilin from the Electrically Conductive Bacterial Nanowires of Geobacter sulfurreducensStructure of the Type IVa Major Pilin from the Electrically Conductive Bacterial Nanowires of Geobacter sulfurreducens
Structural highlights
Publication Abstract from PubMedSeveral species of deltaproteobacteria are capable of reducing insoluble metal oxides as well as other extracellular electron acceptors. These bacteria play a critical role in the cycling of minerals in subsurface environments, sediments, and groundwater. In some species of bacteria, such as Geobacter sulfurreducens, the transport of electrons is proposed to be facilitated by filamentous fibers that are referred to as bacterial nanowires. These nanowires are polymeric assemblies of proteins belonging to the type IVa family of pilin proteins and are mainly comprised of one subunit protein, PilA. Here, we report the high resolution solution nuclear magnetic resonance (NMR) structure of the PilA protein from G. sulfurreducens determined in detergent micelles. The protein is over 85% alpha-helical and exhibits similar architecture to the N-terminal regions of other non-conductive type IVa pilins. The detergent micelle interacts with the first 21 amino acids of the protein, indicating that this region likely associates with the bacterial inner membrane prior to fiber formation. A model of the G. sulfurreducens pilus fiber is proposed based on docking of this structure into the fiber model of the type IVa pilin from Neisseria gonorrhoeae. This model provides insight into the organization of aromatic amino acids that are important for electrical conduction. Structure of the Type IVa Major Pilin from the Electrically Conductive Bacterial Nanowires of Geobacter sulfurreducens.,Reardon PN, Mueller KT J Biol Chem. 2013 Aug 21. PMID:23965997[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
|
| ||||||||||||||||