6gbt: Difference between revisions

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-'''Unreleased structure'''
-The entry 6gbt is ON HOLD  until Paper Publication
+==17beta-hydroxysteroid dehydrogenase type 14 Mutant Y253A in complex with a non-steroidal inhibitor==
+<StructureSection load='6gbt' size='340' side='right'caption='[[6gbt]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors: Badran, M., Klebe, G., Heine, A., Marchais-Oberwinkler, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6gbt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GBT FirstGlance]. <br>
-Description: 17beta-hydroxysteroid dehydrogenase type 14 Mutant Y253A in complex with a non-steroidal inhibitor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=F45:[6-(3,4-DIHYDROXYPHENYL)PYRIDIN-2-YL](4-FLUORO-3-HYDROXYPHENYL)METHANONE'>F45</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbt OCA], [http://pdbe.org/6gbt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gbt RCSB], [http://www.ebi.ac.uk/pdbsum/6gbt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN]] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Badran, M]]
 [[Category: Heine, A]]
-[[Category: Badran, M]]
+[[Category: Klebe, G]]
 [[Category: Marchais-Oberwinkler, S]]
-[[Category: Klebe, G]]
+[[Category: Inhibitor complex mutant]]
+[[Category: Oxidoreductase]]