6e3t: Difference between revisions

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-'''Unreleased structure'''
-The entry 6e3t is ON HOLD  until Paper Publication
+==Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist T1001==
+<StructureSection load='6e3t' size='340' side='right' caption='[[6e3t]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors: Wu, D., Su, X., Lu, J., Li, S., Hood, B., Vasile, S., Potluri, N., Diao, X., Kim, Y., Khorasanizadeh, S., Rastinejad, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6e3t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E3T FirstGlance]. <br>
-Description: Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist T1001
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HO7:(6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole'>HO7</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6e3s|6e3s]]</td></tr>
-[[Category: Li, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e3t OCA], [http://pdbe.org/6e3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e3t RCSB], [http://www.ebi.ac.uk/pdbsum/6e3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e3t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE]] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). [[http://www.uniprot.org/uniprot/EPAS1_MOUSE EPAS1_MOUSE]] Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
+__TOC__
+</StructureSection>
 [[Category: Diao, X]]
-[[Category: Potluri, N]]
+[[Category: Hood, B]]
 [[Category: Khorasanizadeh, S]]
+[[Category: Kim, Y]]
+[[Category: Li, S]]
 [[Category: Lu, J]]
+[[Category: Potluri, N]]
+[[Category: Rastinejad, F]]
+[[Category: Su, X]]
 [[Category: Vasile, S]]
-[[Category: Rastinejad, F]]
 [[Category: Wu, D]]
-[[Category: Kim, Y]]
+[[Category: Antagonist]]
-[[Category: Su, X]]
+[[Category: Complex]]
-[[Category: Hood, B]]
+[[Category: Transcription factor]]
+[[Category: Transcription-transcription inhibitor complex]]