2ky6: Difference between revisions

<StructureSection load='2ky6' size='340' side='right' caption='[[2ky6]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2ky6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KY6 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MED25, ACID1, ARC92, PTOV2, TCBAP0758 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ky6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ky6 OCA], [http://pdbe.org/2ky6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ky6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ky6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ky6 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN]] Charcot-Marie-Tooth disease type 2B2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:19290556</ref>   

[[http://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.<ref>PMID:14657022</ref> <ref>PMID:14983011</ref> <ref>PMID:17641689</ref>