2k6m: Difference between revisions

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 ==Solution Structure of Human Supervillin Headpiece==
-<StructureSection load='2k6m' size='340' side='right' caption='[[2k6m]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''>
+<StructureSection load='2k6m' size='340' side='right'caption='[[2k6m]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2k6m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K6M FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2k6m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6M FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2k6n|2k6n]], [[1yu5|1yu5]], [[1qzp|1qzp]], [[1zv6|1zv6]], [[1qqv|1qqv]], [[1yu7|1yu7]], [[1unc|1unc]], [[1und|1und]], [[1yu8|1yu8]], [[1vii|1vii]], [[2ppz|2ppz]], [[1ujs|1ujs]], [[1yrf|1yrf]], [[1yri|1yri]], [[2jm0|2jm0]], [[1wy3|1wy3]], [[1wy4|1wy4]]</td></tr>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2k6n|2k6n]], [[1yu5|1yu5]], [[1qzp|1qzp]], [[1zv6|1zv6]], [[1qqv|1qqv]], [[1yu7|1yu7]], [[1unc|1unc]], [[1und|1und]], [[1yu8|1yu8]], [[1vii|1vii]], [[2ppz|2ppz]], [[1ujs|1ujs]], [[1yrf|1yrf]], [[1yri|1yri]], [[2jm0|2jm0]], [[1wy3|1wy3]], [[1wy4|1wy4]]</div></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SVIL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SVIL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6m OCA], [http://pdbe.org/2k6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k6m RCSB], [http://www.ebi.ac.uk/pdbsum/2k6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6m ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6m OCA], [https://pdbe.org/2k6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6m RCSB], [https://www.ebi.ac.uk/pdbsum/2k6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6m ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/SVIL_HUMAN SVIL_HUMAN]] Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adehesions involves binding to TRIP6 (By similarity).<ref>PMID:19109420</ref>
+[[https://www.uniprot.org/uniprot/SVIL_HUMAN SVIL_HUMAN]] Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adehesions involves binding to TRIP6 (By similarity).<ref>PMID:19109420</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Brown, J W]]
 [[Category: Didem, V]]