6h0y: Difference between revisions

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'''Unreleased structure'''


The entry 6h0y is ON HOLD
==Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS022==
 
<StructureSection load='6h0y' size='340' side='right'caption='[[6h0y]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6h0y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H0Y FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FHZ:(2~{R})-3-(4-methoxyphenyl)-2-(2~{H}-1,2,3,4-tetrazol-5-yl)propanehydrazide'>FHZ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h0y OCA], [http://pdbe.org/6h0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h0y RCSB], [http://www.ebi.ac.uk/pdbsum/6h0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h0y ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Heinemann, U]]
[[Category: Link, A]]
[[Category: Malecki, P H]]
[[Category: Weiss, M S]]
[[Category: Cancer]]
[[Category: Epigenetic]]
[[Category: Inhibitor design]]
[[Category: Kdm4d]]
[[Category: Ligand binding]]
[[Category: Oxidoreductase]]
[[Category: Tetrazole]]
[[Category: Tetrazolylhydrazide]]

Latest revision as of 18:24, 29 January 2020

Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS022Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS022

Structural highlights

6h0y is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KDM4D_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.[1]

References

  1. ↑ Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell. 2006 May 5;125(3):467-81. Epub 2006 Apr 6. PMID:16603238 doi:10.1016/j.cell.2006.03.028

6h0y, resolution 1.21Å

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