6a96: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6a96 is ON HOLD
+==Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25==
+<StructureSection load='6a96' size='340' side='right' caption='[[6a96]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
-Authors: Liu, S., Xu, L., Guan, F., Liu, Y.T., Cui, Y., Zhang, Q., Bi, G.Q., Zhou, Z.H., Zhang, X., Ye, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6a96]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A96 FirstGlance]. <br>
-Description: Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a96 OCA], [http://pdbe.org/6a96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a96 RCSB], [http://www.ebi.ac.uk/pdbsum/6a96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a96 ProSAT]</span></td></tr>
-[[Category: Bi, G.Q]]
+</table>
-[[Category: Ye, S]]
+== Disease ==
-[[Category: Zhou, Z.H]]
+[[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
+__TOC__
+</StructureSection>
+[[Category: Bi, G Q]]
 [[Category: Cui, Y]]
 [[Category: Guan, F]]
 [[Category: Liu, S]]
+[[Category: Liu, Y T]]
 [[Category: Xu, L]]
-[[Category: Liu, Y.T]]
+[[Category: Ye, S]]
+[[Category: Zhang, Q]]
 [[Category: Zhang, X]]
-[[Category: Zhang, Q]]
+[[Category: Zhou, Z H]]
+[[Category: Iron channel]]
+[[Category: Membrane protein]]