6gxk: Difference between revisions

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-'''Unreleased structure'''
-The entry 6gxk is ON HOLD
+==Crystal structure of Aldo-Keto Reductase 1C3 (AKR1C3) complexed with inhibitor.==
+<StructureSection load='6gxk' size='340' side='right'caption='[[6gxk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-Authors: Goyal, P., Wahlgren, W.Y., Friemann, R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6gxk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GXK FirstGlance]. <br>
-Description: Crystal structure of Aldo-Keto Reductase 1C3 (AKR1C3) complexed with inhibitor.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FFW:4-[[1-(4-chlorophenyl)carbonyl-5-methoxy-2-methyl-indol-3-yl]methyl]-1,2,5-oxadiazol-3-one'>FFW</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gxk OCA], [http://pdbe.org/6gxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gxk RCSB], [http://www.ebi.ac.uk/pdbsum/6gxk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gxk ProSAT]</span></td></tr>
-[[Category: Wahlgren, W.Y]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Friemann, R]]
 [[Category: Goyal, P]]
-[[Category: Friemann, R]]
+[[Category: Wahlgren, W Y]]
+[[Category: Akr1c3]]
+[[Category: Aldo-keto reductase 1c3]]
+[[Category: Bioisosterism]]
+[[Category: Crpc]]
+[[Category: Inhibitor]]
+[[Category: Oxidoreductase]]
+[[Category: Prostate cancer]]
+[[Category: Scaffold hopping]]