6fdf: Difference between revisions

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==Crystal structure of S. pombe Dnmt2 methyltransferase==
==Crystal structure of S. pombe Dnmt2 methyltransferase==
<StructureSection load='6fdf' size='340' side='right' caption='[[6fdf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='6fdf' size='340' side='right'caption='[[6fdf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fdf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FDF FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fdf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FDF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.697&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fdd|6fdd]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(cytosine(38)-C(5))-methyltransferase tRNA (cytosine(38)-C(5))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.204 2.1.1.204] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fdf OCA], [https://pdbe.org/6fdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fdf RCSB], [https://www.ebi.ac.uk/pdbsum/6fdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fdf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fdf OCA], [http://pdbe.org/6fdf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fdf RCSB], [http://www.ebi.ac.uk/pdbsum/6fdf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fdf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PMT1M_SCHPO PMT1M_SCHPO]] Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Can also methylate cytosine 38 in tRNA(Glu), albeit to a lower level, but not tRNA(Lys). Pmt1-dependent tRNA methylation is induced by nitrogen limitation and depends on the nutrient-sensing protein kinase sck2. Does not have DNA-methylation activity.<ref>PMID:23074192</ref>
[https://www.uniprot.org/uniprot/PMT1M_SCHPO PMT1M_SCHPO] Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Can also methylate cytosine 38 in tRNA(Glu), albeit to a lower level, but not tRNA(Lys). Pmt1-dependent tRNA methylation is induced by nitrogen limitation and depends on the nutrient-sensing protein kinase sck2. Does not have DNA-methylation activity.<ref>PMID:23074192</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6fdf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6fdf" style="background-color:#fffaf0;"></div>
==See Also==
*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ficner, R]]
[[Category: Large Structures]]
[[Category: Johannsson, S]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Neumann, P]]
[[Category: Ficner R]]
[[Category: Dnmt2]]
[[Category: Johannsson S]]
[[Category: Methyltransferase]]
[[Category: Neumann P]]
[[Category: S-adenosylhomocysteine]]
[[Category: Transferase]]
[[Category: Trna]]

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