6die: Difference between revisions

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-'''Unreleased structure'''
-The entry 6die is ON HOLD  until Paper Publication
+==Crystal structure of Tdp1 catalytic domain in complex with Zenobia fragment benzene-1,2,4-tricarboxylic acid from single soak==
+<StructureSection load='6die' size='340' side='right'caption='[[6die]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
-Authors: Lountos, G.T., Zhao, X.Z., Kiselev, E., Tropea, J.E., Needle, D., Burke Jr., T.R., Pommier, Y., Waugh, D.S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6die]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DIE FirstGlance]. <br>
-Description: Crystal structure of Tdp1 catalytic domain in complex with Zenobia fragment benzene-1,2,4-tricarboxylic acid from single soak
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GHM:benzene-1,2,4-tricarboxylic+acid'>GHM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6die FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6die OCA], [http://pdbe.org/6die PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6die RCSB], [http://www.ebi.ac.uk/pdbsum/6die PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6die ProSAT]</span></td></tr>
-[[Category: T.R]]
+</table>
-[[Category: Pommier, Y]]
+== Disease ==
-[[Category: Waugh, D.S]]
+[[http://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] Defects in TDP1 are the cause of spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1) [MIM:[http://omim.org/entry/607250 607250]]. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.<ref>PMID:16141202</ref> <ref>PMID:15647511</ref> <ref>PMID:12244316</ref> <ref>PMID:17948061</ref> <ref>PMID:15920477</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.<ref>PMID:12023295</ref> <ref>PMID:15111055</ref> <ref>PMID:15811850</ref> <ref>PMID:16141202</ref> <ref>PMID:22822062</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Burke, T R]]
 [[Category: Kiselev, E]]
-[[Category: Zhao, X.Z]]
+[[Category: Lountos, G T]]
-[[Category: Tropea, J.E]]
-[[Category: Burke Jr]]
 [[Category: Needle, D]]
-[[Category: Lountos, G.T]]
+[[Category: Pommier, Y]]
+[[Category: Tropea, J E]]
+[[Category: Waugh, D S]]
+[[Category: Zhao, X Z]]
+[[Category: Fragment-based drug design]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]