2j5y: Difference between revisions

Revision as of 08:23, 4 May 2008

CRYSTAL STRUCTURE OF THE GA MODULE FROM F.MAGNA

OverviewOverview

The albumin-binding domain, or GA module, of the peptostreptococcal albumin-binding protein expressed in pathogenic strains of Finegoldia magna is believed to be responsible for the virulence and increased growth rate of these strains. Here we present the 1.4A crystal structure of this domain, and compare it with the crystal structure of the GA-albumin complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA module is "sticky", and is capable of forming contacts with a range of protein surfaces. This might lead to interactions with different host proteins.

About this StructureAbout this Structure

2J5Y is a Single protein structure of sequence from Finegoldia magna. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:17575979 Page seeded by OCA on Sun May 4 08:23:28 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2j5y.gif|left|200px]]
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 '''CRYSTAL STRUCTURE OF THE GA MODULE FROM F.MAGNA'''
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 [[Category: Nordberg, P A.]]
 [[Category: Valegard, K.]]
-[[Category: cell wall]]
+[[Category: Cell wall]]
-[[Category: peptidoglycan-anchor]]
+[[Category: Peptidoglycan-anchor]]
-[[Category: protein binding bacterial albumin-binding three-helix bundle]]
+[[Category: Protein binding bacterial albumin-binding three-helix bundle]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:23:28 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:53:25 2008''