Glycoprotein GP: Difference between revisions

Revision as of 13:30, 15 July 2019

Function

The virus contains a surface glycoprotein PG that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes. GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of GP1 and GP2 ^[1]. Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor. The GP2 subunit is thought to mediate membrane fusion.

For details see GP1 of Lassa Virus.

3D Structures of glycoprotein GP

Glycoprotein GP 3D structures

Ebolavirus glycosylated GP1 (wheat) and GP2 (blue) complex with antibody heavy chain (red) and light chain (aqua) (PDB code 3s88)

Drag the structure with the mouse to rotate

3D Structures of glycoprotein GP3D Structures of glycoprotein GP

Updated on 15-July-2019

ReferencesReferences

↑ Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS. Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:10077567

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

[1] Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS. Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:10077567

[1]

@@ Line 8: / Line 8: @@
 For details see [[GP1 of Lassa Virus]].
-== Disease ==
+== 3D Structures of glycoprotein GP ==
+[[Glycoprotein GP 3D structures]]
-== Relevance ==
-== Structural highlights ==
 </StructureSection>
@@ Line 29: / Line 26: @@
 **[[3lj5]], [[4v4k]] – GP1 – Bacteriophage p22 <br />
 **[[4n21]], [[4n23]] – GP2 ectodomain – CAS virus <br />
+**[[5jq3]] – ZevGP1 + GP2 – Zaire ebolavirus <br />
 *Glycoprotein GP complex
 **[[3ve0]], [[3s88]] – GP1 + GP2 + antibody – Sudan ebolavirus <br />
-**[[5f1b]] – ZevGP1 + GP2 + Niemann-Pick C1 protein – Zaire ebolavirus <br />
+**[[5f1b]] – ZevGP1 + GP2 + Niemann-Pick C1 protein <br />
+**[[5jnx]] – ZevGP1 (mutant) + GP2 + Niemann-Pick C1 protein – Cryo EM<br />
 **[[6f5u]], [[6f6i]], [[6f6n]], [[6f6s]] – ZevGP1 + GP2 + antidepressant <br />
-**[[3csy]], [[5kel]], [[5ken]] – ZevGP1 + GP2 + antibody <br />
+**[[5jqb]] – ZevGP1 + GP2 + ibuprofen<br />
-**[[5uqy]] – GP1 + GP2 + antibody – Marburg virus <br />
+**[[5jq7]] – ZevGP1 + GP2 + toremifene<br />
+**[[6g9i]], [[6g9b]], [[6g95]] – ZevGP1 (mutant) + GP2 (mutant) + antidepressant <br />
+**[[6hs4]], [[6hro]] – ZevGP1 (mutant) + GP2 (mutant) + inhibitor <br />
+**[[3csy]], [6mam]], [[6eay]], [[6ea7]], [[5hj3]], [[5hfc]] – ZevGP1 + GP2 + antibody <br />
+**[[5kel]], [[5ken]], [[6dzl]] – ZevGP1 + GP2 + antibody - Cryo EM<br />
+**[[6dzm]] – GP1 + GP2 + antibody – Bundibugyo ebolavirus - Cryo EM<br />
+**[[5uqy]], [[6bp2]] – GP1 + GP2 + antibody – Marburg virus <br />
 **[[3kas]] – MvGP1 + transferrin receptor 1 <br />
 **[[5nuz]] – GP1 + antibody – Junin virus <br />