User:Luis Netto/Sandbox 1: Difference between revisions

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Ohr is a Cys based peroxidase that means the active site Cys is very reactive towards organic hydroperoxides. This high reactivity is achieved in the active site by interactions with fully conserved Arg and Glu residues among others

~~==Your Heading Here (maybe something like 'Structure')==~~

~~Anything in this section will appear adjacent to the 3D structure and will be scrollable.~~

~~</StructureSection>~~

~~It is involved in the response of~~

== Disease ==

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== Structural highlights ==

Ohr is a homo-dimer, with a symmetrical,oval shape. The two monomers are tightly wrapped around each other in a head-to-tail orientation to generate a compact quaternary structure.

Ohr is a homo-dimer, with a symmetrical,oval shape. The two monomers are tightly wrapped around each other in a head-to-tail orientation to generate a compact quaternary structure (Figure 1).

[[Image:Homodimer_Ohr.png|thumb|Figure1 Ohr homodimer]]

~~One~~ monomer is depicted in light blue the other in green. Reactive Cys also called peroxidatic Cys (CP) is depicted in orange. Catalytic Arg (red) and Glu (pink) compose the catalytic triad with CP

In Figure 1, one monomer is depicted in light blue the other in green. Reactive Cys also called peroxidatic Cys (Cp) is depicted in orange. Catalytic Arg (red) and Glu (pink) compose the catalytic triad with Cp. The catalytic Glu orientates the catalytic Arg towards Cp, increasing its nucleophilicity.

@@ Line 12: / Line 12: @@
 Ohr is a Cys based peroxidase that means the active site Cys is very reactive towards organic hydroperoxides. This high reactivity is achieved in the active site by interactions with fully conserved Arg and Glu residues among others
-==Your Heading Here (maybe something like 'Structure')==
-Anything in this section will appear adjacent to the 3D structure and will be scrollable.
-</StructureSection>
-It is involved in the response of
 == Disease ==
@@ Line 44: / Line 35: @@
 == Structural highlights ==
-Ohr is a homo-dimer, with a symmetrical,oval shape. The two monomers are tightly wrapped around each other in a head-to-tail orientation to generate a compact quaternary structure.
+Ohr is a homo-dimer, with a symmetrical,oval shape. The two monomers are tightly wrapped around each other in a head-to-tail orientation to generate a compact quaternary structure (Figure 1).
 [[Image:Homodimer_Ohr.png|thumb|Figure1 Ohr homodimer]]
-One monomer is depicted in light blue the other in green. Reactive Cys also called peroxidatic Cys (CP) is depicted in orange. Catalytic Arg (red) and Glu (pink) compose the catalytic triad with CP
+In Figure 1, one monomer is depicted in light blue the other in green. Reactive Cys also called peroxidatic Cys (Cp) is depicted in orange. Catalytic Arg (red) and Glu (pink) compose the catalytic triad with Cp. The catalytic Glu orientates the catalytic Arg towards Cp, increasing its nucleophilicity.