2d9w: Difference between revisions
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==Solution structure of the PH domain of Docking protein 2 from human== | ==Solution structure of the PH domain of Docking protein 2 from human== | ||
<StructureSection load='2d9w' size='340' side='right' caption='[[2d9w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2d9w' size='340' side='right'caption='[[2d9w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2d9w]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2d9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9W FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOK2 ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9w OCA], [https://pdbe.org/2d9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9w RCSB], [https://www.ebi.ac.uk/pdbsum/2d9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9w ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9w TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/DOK2_HUMAN DOK2_HUMAN]] DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Inoue, M]] | [[Category: Inoue, M]] | ||
[[Category: Kigawa, T]] | [[Category: Kigawa, T]] | ||
Revision as of 14:57, 3 February 2021
Solution structure of the PH domain of Docking protein 2 from humanSolution structure of the PH domain of Docking protein 2 from human
Structural highlights
Function[DOK2_HUMAN] DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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