2ibl: Difference between revisions

Revision as of 07:17, 4 May 2008

Crystal structure of a helper molecule (HT-mf-thromb) based on mini-fibritin (mf) crystal structure (pdb:1OX3).

OverviewOverview

Hantaviruses can cause hemorrhagic fever with a renal syndrome and hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid protein of hantaviruses encapsidates viral genomic RNA and associates with transcription and replication complexes. Both the amino and carboxy termini of the nucleocapsid protein had been predicted to form trimers prior to the formation of the ribonucleoprotein. Crystal structures of amino-terminal fragments of the nucleocapsid protein showed the formation of intramolecular antiparallel coiled coils, but not intermolecular trimers. Thus, the amino-terminal part of the nucleocapsid protein is probably insufficient to initiate the trimerization of the full-length molecule.

About this StructureAbout this Structure

2IBL is a Single protein structure of sequence from Unidentified phage. Full crystallographic information is available from OCA.

ReferenceReference

The coiled-coil domain structure of the Sin Nombre virus nucleocapsid protein., Boudko SP, Kuhn RJ, Rossmann MG, J Mol Biol. 2007 Mar 9;366(5):1538-44. Epub 2006 Dec 23. PMID:17222867 Page seeded by OCA on Sun May 4 07:17:56 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2ibl.jpg|left|200px]]
- {{Structure
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-|GENE= wac ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=38018 unidentified phage])
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-|DOMAIN=
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-|RELATEDENTRY=[[1ox3|1OX3]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ibl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ibl OCA], [http://www.ebi.ac.uk/pdbsum/2ibl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ibl RCSB]</span>
-}}
 '''Crystal structure of a helper molecule (HT-mf-thromb) based on mini-fibritin (mf) crystal structure (pdb:1OX3).'''
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 [[Category: Boudko, S P.]]
 [[Category: Rossmann, M G.]]
-[[Category: bacteriophage t4]]
+[[Category: Bacteriophage t4]]
-[[Category: foldon]]
+[[Category: Foldon]]
-[[Category: helper molecule]]
+[[Category: Helper molecule]]
-[[Category: mini-fibritin]]
+[[Category: Mini-fibritin]]
-[[Category: trimerization]]
+[[Category: Trimerization]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:17:56 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:42:04 2008''