2bj6: Difference between revisions
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==Crystal Structure of a decameric HNA-RNA hybrid== | ==Crystal Structure of a decameric HNA-RNA hybrid== | ||
<StructureSection load='2bj6' size='340' side='right' caption='[[2bj6]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2bj6' size='340' side='right'caption='[[2bj6]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bj6]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BJ6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2bj6]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BJ6 FirstGlance]. <br> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Herdewijn, P]] | [[Category: Herdewijn, P]] | ||
[[Category: Maier, T]] | [[Category: Maier, T]] | ||
Revision as of 10:58, 19 February 2020
Crystal Structure of a decameric HNA-RNA hybridCrystal Structure of a decameric HNA-RNA hybrid
Structural highlights
Publication Abstract from PubMedThe crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids. Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.,Maier T, Przylas I, Strater N, Herdewijn P, Saenger W J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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