6d8h: Difference between revisions

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'''Unreleased structure'''


The entry 6d8h is ON HOLD until Paper Publication
==NMR solution structure of tamapin, mutant Y31+N==
 
<StructureSection load='6d8h' size='340' side='right'caption='[[6d8h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6d8h]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D8H FirstGlance]. <br>
Description:  
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d8h OCA], [http://pdbe.org/6d8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d8h RCSB], [http://www.ebi.ac.uk/pdbsum/6d8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d8h ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KAX54_MESTA KAX54_MESTA]] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.<ref>PMID:12239213</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Delgado, G A.Titaux]]
[[Category: Flores, M Mayorga]]
[[Category: Meneses, C M.Melchor]]
[[Category: Portilla, F del Rio]]
[[Category: Csalpha/beta]]
[[Category: Sk channel]]
[[Category: Tamapin mutant]]
[[Category: Toxin]]
[[Category: Y31+n]]

Revision as of 11:44, 1 May 2019

NMR solution structure of tamapin, mutant Y31+NNMR solution structure of tamapin, mutant Y31+N

Structural highlights

6d8h is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KAX54_MESTA] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.[1]

References

  1. ↑ Pedarzani P, D'hoedt D, Doorty KB, Wadsworth JD, Joseph JS, Jeyaseelan K, Kini RM, Gadre SV, Sapatnekar SM, Stocker M, Strong PN. Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. J Biol Chem. 2002 Nov 29;277(48):46101-9. Epub 2002 Sep 17. PMID:12239213 doi:http://dx.doi.org/10.1074/jbc.M206465200
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