2arw: Difference between revisions
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==The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor== | ==The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor== | ||
<StructureSection load='2arw' size='340' side='right' caption='[[2arw]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | <StructureSection load='2arw' size='340' side='right'caption='[[2arw]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2arw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ARW FirstGlance]. <br> | <table><tr><td colspan='2'>[[2arw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ARW FirstGlance]. <br> | ||
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==See Also== | ==See Also== | ||
*[[Interleukin receptor|Interleukin receptor]] | *[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Dingley, A J]] | [[Category: Dingley, A J]] | ||
[[Category: Grotzinger, J]] | [[Category: Grotzinger, J]] | ||
Revision as of 08:21, 13 February 2020
The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptorThe solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor
Structural highlights
Function[IL6RA_HUMAN] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.[1] [2] Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.[3] [4] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytokine receptor homology region consisting of two fibronectin type III-like domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On target cells, interleukin-6 (IL-6) initially binds to its cognate alpha-receptor and subsequently to a homodimer of the signal transducer receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular domains. The N-terminal immunoglobulin-like domain is not involved in ligand binding, whereas the third membrane-proximal fibronectin-like domain (IL-6R-D3) accounts for more than 90% of the binding energy to IL-6. Here, we present the solution structure of the IL-6R-D3 domain solved by multidimensional heteronuclear NMR spectroscopy. The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor.,Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grotzinger J Biol Chem. 2006 Sep;387(9):1255-9. PMID:16972794[5] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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