2aot: Difference between revisions
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==Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine== | ==Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine== | ||
<StructureSection load='2aot' size='340' side='right' caption='[[2aot]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2aot' size='340' side='right'caption='[[2aot]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2aot]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2aot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AOT FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PM:N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE'>2PM</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PM:N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE'>2PM</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jqd|1jqd]], [[1jqe|1jqe]], [[2aou|2aou]], [[2aov|2aov]], [[2aow|2aow]], [[2aox|2aox]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jqd|1jqd]], [[1jqe|1jqe]], [[2aou|2aou]], [[2aov|2aov]], [[2aow|2aow]], [[2aox|2aox]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HNMT ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HNMT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histamine_N-methyltransferase Histamine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.8 2.1.1.8] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aot OCA], [https://pdbe.org/2aot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aot RCSB], [https://www.ebi.ac.uk/pdbsum/2aot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aot ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/HNMT_HUMAN HNMT_HUMAN]] Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Histamine N-methyltransferase]] | [[Category: Histamine N-methyltransferase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Cheng, X]] | [[Category: Cheng, X]] | ||
[[Category: Horton, J R]] | [[Category: Horton, J R]] |