User:Andrea Foote/Sandbox 1: Difference between revisions

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== Introduction ==

'''Purine-rich element binding protein alpha (Purα)''' is a transcription factor with a molecular weight of ~35 kDa encoded by the ''PURA'' gene. It possesses ATP-independent dsDNA unwinding activity, and is known to bind sequence-specific purine-rich regions of ssDNA and ssRNA, recognizing GGN motifs. Purα is a member of the PUR family of proteins, which includes Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) encoded by the ''Acta2'' gene. It is also known to be involved in DNA replication and cell cycle regulation, as well as mRNA translation. It plays a crucial role in nervous system development, and has been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section).<ref>PMID:26744780</ref>

[[Image:180503 PurA dimer.jpg|thumb|center|~~800px~~| Artist representation of a Purα homodimer (linkers between repeats I-II and III (red) were drawn in PowerPoint and are NOT to scale). NOTE: This is NOT a verified model, but a rough placement to show all three repeats together. It is not known what the orientation of these domains are relative to one another. (Repeat I-II ([[5fgp]]): purple (I) and orange (II), repeat III ([[5fgo]]): cyan).]]

[[Image:180503 PurA dimer.jpg|thumb|center|700px| Artist representation of a Purα homodimer (linkers between repeats I-II and III (red) were drawn in PowerPoint and are NOT to scale). NOTE: This is NOT a verified model, but a rough placement to show all three repeats together. It is not known what the orientation of these domains are relative to one another. (Repeat I-II ([[5fgp]]): purple (I) and orange (II), repeat III ([[5fgo]]): cyan).]]

== Structure ==

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 == Introduction ==
 '''Purine-rich element binding protein alpha (Purα)'''  is a transcription factor with a molecular weight of ~35 kDa encoded by the ''PURA'' gene. It possesses ATP-independent dsDNA unwinding activity, and is known to bind sequence-specific purine-rich regions of ssDNA and ssRNA, recognizing GGN motifs. Purα is a member of the PUR family of proteins, which includes Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) encoded by the ''Acta2'' gene. It is also known to be involved in DNA replication and cell cycle regulation, as well as mRNA translation. It plays a crucial role in nervous system development, and has been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section).<ref>PMID:26744780</ref>
-[[Image:180503 PurA dimer.jpg|thumb|center|800px| Artist representation of a Purα homodimer (linkers between repeats I-II and III (red) were drawn in PowerPoint and are NOT to scale). NOTE: This is NOT a verified model, but a rough placement to show all three repeats together. It is not known what the orientation of these domains are relative to one another.  (Repeat I-II ([[5fgp]]): purple (I) and orange (II), repeat III ([[5fgo]]): cyan).]]
+[[Image:180503 PurA dimer.jpg|thumb|center|700px| Artist representation of a Purα homodimer (linkers between repeats I-II and III (red) were drawn in PowerPoint and are NOT to scale). NOTE: This is NOT a verified model, but a rough placement to show all three repeats together. It is not known what the orientation of these domains are relative to one another.  (Repeat I-II ([[5fgp]]): purple (I) and orange (II), repeat III ([[5fgo]]): cyan).]]
 == Structure ==