2hth: Difference between revisions

Revision as of 06:41, 4 May 2008

Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain

OverviewOverview

The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.

About this StructureAbout this Structure

2HTH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain., Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI, Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22. PMID:17057716 Page seeded by OCA on Sun May 4 06:41:26 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2hth.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2hth |SIZE=350|CAPTION= <scene name='initialview01'>2hth</scene>, resolution 2.70&Aring;
+The line below this paragraph, containing "STRUCTURE_2hth", creates the "Structure Box" on the page.
-|SITE=
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-|GENE= RPS27A, UBA52, UBB, UBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_2hth|  PDB=2hth  |  SCENE=  }}
-|RELATEDENTRY=[[2cay|2CAY]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hth OCA], [http://www.ebi.ac.uk/pdbsum/2hth PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hth RCSB]</span>
-}}
 '''Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain'''
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 [[Category: Sundquist, W I.]]
 [[Category: Whitby, F G.]]
-[[Category: glue domain]]
+[[Category: Glue domain]]
-[[Category: ph domain]]
+[[Category: Ph domain]]
-[[Category: protein sorting]]
+[[Category: Protein sorting]]
-[[Category: ubiquitin complex]]
+[[Category: Ubiquitin complex]]
-[[Category: viral budding]]
+[[Category: Viral budding]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:41:26 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:35:12 2008''