2hn7: Difference between revisions
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{{STRUCTURE_2hn7| PDB=2hn7 | SCENE= }} | |||
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'''HLA-A*1101 in complex with HBV peptide homologue''' | '''HLA-A*1101 in complex with HBV peptide homologue''' | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Blicher, T.]] | [[Category: Blicher, T.]] | ||
[[Category: | [[Category: Hbv]] | ||
[[Category: | [[Category: Hepatitis b virus]] | ||
[[Category: | [[Category: Hla]] | ||
[[Category: | [[Category: Human leukocyte antigen]] | ||
[[Category: | [[Category: Immunoglobulin family]] | ||
[[Category: | [[Category: Major histocompatibility complex class i]] | ||
[[Category: | [[Category: Mhc-i]] | ||
[[Category: | [[Category: Peptide-mhc-complex]] | ||
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Revision as of 06:28, 4 May 2008
HLA-A*1101 in complex with HBV peptide homologue
OverviewOverview
A high-resolution structure of the human MHC-I molecule HLA-A*1101 is presented in which it forms a complex with a sequence homologue of a peptide that occurs naturally in hepatitis B virus DNA polymerase. The sequence of the bound peptide is AIMPARFYPK, while that of the corresponding natural peptide is LIMPARFYPK. The peptide does not make efficient use of the middle E pocket for binding, which leads to a rather superficial and exposed binding mode for the central peptide residues. Despite this, the peptide binds with high affinity (IC50 of 31 nM).
DiseaseDisease
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]
About this StructureAbout this Structure
2HN7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue., Blicher T, Kastrup JS, Pedersen LO, Buus S, Gajhede M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1179-84. Epub 2006 Nov 4. PMID:17142892 Page seeded by OCA on Sun May 4 06:28:49 2008