User:Andrea Foote/Sandbox 1: Difference between revisions
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== Introduction == | == Introduction == | ||
'''Purine-rich element binding protein alpha''' (Purα or PurA) is a transcription factor with a molecular weight of ~35 kDa encoded by the PURA gene. It is known to recognize and bind sequence-specific purine-rich regions of ssDNA and ssRNA. Purα is a member of the PUR family of proteins, including cousins Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) and ____. It plays a crucial role in nervous system development, and additionally is known to be involved in cell cycle regulation. Mutations in Purα have been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section). | '''Purine-rich element binding protein alpha''' (Purα or PurA) is a transcription factor with a molecular weight of ~35 kDa encoded by the PURA gene. It is known to recognize and bind sequence-specific purine-rich regions of ssDNA and ssRNA. Purα is a member of the PUR family of proteins, including cousins Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) and ____. It plays a crucial role in nervous system development, and additionally is known to be involved in cell cycle regulation. Mutations in Purα have been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section). | ||
== Structure == | == Structure == | ||