User:Andrea Foote/Sandbox 1: Difference between revisions
Andrea Foote (talk | contribs) No edit summary |
Andrea Foote (talk | contribs) No edit summary |
||
| Line 2: | Line 2: | ||
<StructureSection load='5fgp' size='340' side='right' caption='''Drosophila'' Purα repeats I-II bound to DNA' scene='78/786627/5fgp_intro/6'> | <StructureSection load='5fgp' size='340' side='right' caption='''Drosophila'' Purα repeats I-II bound to DNA' scene='78/786627/5fgp_intro/6'> | ||
== Introduction == | == Introduction == | ||
Purine-rich element binding protein alpha (Purα or PurA), encoded by the PURA gene is a transcription factor with a molecular weight of ~35 kDa. It is known to recognize and bind sequence specific purine-rich regions of ssDNA and ssRNA. Purα is a member of the PUR family of proteins, which includes cousins Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of genes encoding smooth muscle alpha actin (SMαA) and ____. It also plays a crucial role in nervous system development and is known to be involved in cell cycle regulation. Mutations in Purα have been implicated in two neurological diseases: Purα Syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section). | ''Purine-rich element binding protein alpha'' (Purα or PurA), encoded by the PURA gene is a transcription factor with a molecular weight of ~35 kDa. It is known to recognize and bind sequence specific purine-rich regions of ssDNA and ssRNA. Purα is a member of the PUR family of proteins, which includes cousins Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of genes encoding smooth muscle alpha actin (SMαA) and ____. It also plays a crucial role in nervous system development and is known to be involved in cell cycle regulation. Mutations in Purα have been implicated in two neurological diseases: Purα Syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section). | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
Revision as of 23:23, 27 April 2018
Purine-rich element binding protein alphaPurine-rich element binding protein alpha
IntroductionPurine-rich element binding protein alpha (Purα or PurA), encoded by the PURA gene is a transcription factor with a molecular weight of ~35 kDa. It is known to recognize and bind sequence specific purine-rich regions of ssDNA and ssRNA. Purα is a member of the PUR family of proteins, which includes cousins Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of genes encoding smooth muscle alpha actin (SMαA) and ____. It also plays a crucial role in nervous system development and is known to be involved in cell cycle regulation. Mutations in Purα have been implicated in two neurological diseases: Purα Syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section). You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. Structurefacilitates dimerization of Purα monomers. The association of two repeat III domains forms what is termed the "intermolecular domain". Functionfunctions as a homodimer or heterodimer with PurB (and PurG?), PurA is known to repress various genes including , Y57 (repeat I) and F145 (repeat II) have been implicated in the DNA unwinding activity of PurA.[3] DiseaseRelevanceStructural highlightsThis is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
|
| ||||||||||
ReferencesReferences
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Weber J, Bao H, Hartlmuller C, Wang Z, Windhager A, Janowski R, Madl T, Jin P, Niessing D. Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha. Elife. 2016 Jan 8;5. pii: e11297. doi: 10.7554/eLife.11297. PMID:26744780 doi:http://dx.doi.org/10.7554/eLife.11297