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==Crystal structure of the T3D reovirus sigma1 coiled coil tail and body== | |||
<StructureSection load='6gap' size='340' side='right' caption='[[6gap]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6gap]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GAP FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gap OCA], [http://pdbe.org/6gap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gap RCSB], [http://www.ebi.ac.uk/pdbsum/6gap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gap ProSAT]</span></td></tr> | |||
[[ | </table> | ||
[[Category: Dietrich, M | == Function == | ||
[[http://www.uniprot.org/uniprot/SIGM1_REOVD SIGM1_REOVD]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dietrich, M H]] | |||
[[Category: Stehle, T]] | [[Category: Stehle, T]] | ||
[[Category: Beta-spiral repeat]] | |||
[[Category: Cell attachment protein]] | |||
[[Category: Coiled coil]] | |||
[[Category: Reovirus sigma1]] | |||
[[Category: Viral protein]] | |||
Revision as of 08:40, 25 April 2018
Crystal structure of the T3D reovirus sigma1 coiled coil tail and bodyCrystal structure of the T3D reovirus sigma1 coiled coil tail and body
Structural highlights
Function[SIGM1_REOVD] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. |
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