2gom: Difference between revisions

Revision as of 05:20, 4 May 2008

Crystal structure of Efb-C from Staphylococcus aureus

OverviewOverview

To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.

About this StructureAbout this Structure

2GOM is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

ReferenceReference

A structural basis for complement inhibition by Staphylococcus aureus., Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV, Nat Immunol. 2007 Apr;8(4):430-7. Epub 2007 Mar 11. PMID:17351618 Page seeded by OCA on Sun May 4 05:20:33 2008

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OCA

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 [[Image:2gom.jpg|left|200px]]
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-|GENE= efb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
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-}}
 '''Crystal structure of Efb-C from Staphylococcus aureus'''
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 [[Category: Geisbrecht, B V.]]
 [[Category: Hammel, M.]]
-[[Category: three-helix closed bundle with left-hand twist]]
+[[Category: Three-helix closed bundle with left-hand twist]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:20:33 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:19:27 2008''