Histamine H1 receptor: Difference between revisions
Ann Taylor (talk | contribs) New page: ==Histamine H1 Receptor== <StructureSection load='3RZE' size='340' side='right' caption='Histamine H1 receptor with an antagonist' scene=''> Allergy symptoms are mostly caused by the relea... |
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== Structural highlights == | == Structural highlights == | ||
The structure of the H1 histamine receptor bound to an antihistamine, doxepin was published in 2011 <ref>PMID:21697825</ref>. | The structure of the H1 histamine receptor bound to an antihistamine, doxepin was published in 2011 <ref>PMID:21697825</ref>. A <scene name='78/784820/N_to_c_rainbow/1'>N-->C rainbow</scene> view colors the N terminus blue and the C terminus red, with the intervening segments paralleling the rainbow (blue, green, yellow, orange, red). This image is oriented with the transmembrane section at the top and the cytosolic portion below. | ||
<scene name='78/784820/Doxepin/2'>Doxepin</scene> binds among the transmembrane alpha helices. Binding is stabilized by a number of <scene name='78/784820/Interacting_amino_acids/1'>interactions with amino acids</scene>. Interestingly, second generation antihistamines take advantage of an anion binding site formed by <scene name='78/784820/Lys/2'>two lysine residues</scene>; in this structure, they interact with a phosphate. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||