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'''Structure of the S-adenosylmethionine riboswitch mRNA regulatory element''' | '''Structure of the S-adenosylmethionine riboswitch mRNA regulatory element''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIS OCA]. | |||
==Reference== | ==Reference== | ||
Structure of the S-adenosylmethionine riboswitch regulatory mRNA element., Montange RK, Batey RT, Nature. 2006 Jun 29;441(7097):1172-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16810258 16810258] | Structure of the S-adenosylmethionine riboswitch regulatory mRNA element., Montange RK, Batey RT, Nature. 2006 Jun 29;441(7097):1172-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16810258 16810258] | ||
[[Category: Batey, R T.]] | [[Category: Batey, R T.]] | ||
[[Category: Montange, R K.]] | [[Category: Montange, R K.]] | ||
[[Category: | [[Category: Mrna]] | ||
[[Category: | [[Category: Riboswitch]] | ||
[[Category: | [[Category: Rna-ligand complex]] | ||
[[Category: | [[Category: S-adenosylmethionine]] | ||
[[Category: | [[Category: Sam]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:09:11 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 05:09, 4 May 2008
Structure of the S-adenosylmethionine riboswitch mRNA regulatory element
OverviewOverview
Riboswitches are cis-acting genetic regulatory elements found in the 5'-untranslated regions of messenger RNAs that control gene expression through their ability to bind small molecule metabolites directly. Regulation occurs through the interplay of two domains of the RNA: an aptamer domain that responds to intracellular metabolite concentrations and an expression platform that uses two mutually exclusive secondary structures to direct a decision-making process. In Gram-positive bacteria such as Bacillus species, riboswitches control the expression of more than 2% of all genes through their ability to respond to a diverse set of metabolites including amino acids, nucleobases and protein cofactors. Here we report the 2.9-angstroms resolution crystal structure of an S-adenosylmethionine (SAM)-responsive riboswitch from Thermoanaerobacter tengcongensis complexed with S-adenosylmethionine, an RNA element that controls the expression of several genes involved in sulphur and methionine metabolism. This RNA folds into a complex three-dimensional architecture that recognizes almost every functional group of the ligand through a combination of direct and indirect readout mechanisms. Ligand binding induces the formation of a series of tertiary interactions with one of the helices, serving as a communication link between the aptamer and expression platform domains.
About this StructureAbout this Structure
Full crystallographic information is available from OCA.
ReferenceReference
Structure of the S-adenosylmethionine riboswitch regulatory mRNA element., Montange RK, Batey RT, Nature. 2006 Jun 29;441(7097):1172-5. PMID:16810258 Page seeded by OCA on Sun May 4 05:09:11 2008