2gcu: Difference between revisions

Revision as of 04:57, 4 May 2008

X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580

OverviewOverview

The protein product of gene At1g53580 from Arabidopsis thaliana possesses 54% sequence identity to a human enzyme that has been implicated in the rare disorder ethylmalonic encephalopathy. The structure of the At1g53580 protein has been solved to a nominal resolution of 1.48 Angstrom. This structure reveals tertiary structure differences between the ETHE1-like enzyme and glyoxalase II enzymes that are likely to account for differences in reaction chemistry and multimeric state between the two types of enzymes. In addition, the Arabidopsis ETHE1 protein is used as a model to explain the significance of several mutations in the human enzyme that have been observed in patients with ethylmalonic encephalopathy.

About this StructureAbout this Structure

2GCU is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

ReferenceReference

Structure of an ETHE1-like protein from Arabidopsis thaliana., McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN Jr, Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):964-70. Epub 2006, Aug 19. PMID:16929096 Page seeded by OCA on Sun May 4 04:57:35 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2gcu.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2gcu |SIZE=350|CAPTION= <scene name='initialview01'>2gcu</scene>, resolution 1.477&Aring;
+The line below this paragraph, containing "STRUCTURE_2gcu", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CSW:CYSTEINE-S-DIOXIDE'>CSW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxyacylglutathione_hydrolase Hydroxyacylglutathione hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.6 3.1.2.6] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= At1g53580 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])
+-->
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0491 GloB]</span>
+{{STRUCTURE_2gcu|  PDB=2gcu  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gcu OCA], [http://www.ebi.ac.uk/pdbsum/2gcu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gcu RCSB]</span>
-}}
 '''X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580'''
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 [[Category: McCoy, J G.]]
 [[Category: Wesenberg, G E.]]
-[[Category: center for eukaryotic structural genomic]]
+[[Category: Center for eukaryotic structural genomic]]
-[[Category: cesg]]
+[[Category: Cesg]]
-[[Category: ethe1]]
+[[Category: Ethe1]]
-[[Category: ethylmalonic encephalopathy]]
+[[Category: Ethylmalonic encephalopathy]]
-[[Category: protein structure initiative]]
+[[Category: Protein structure initiative]]
-[[Category: psi]]
+[[Category: Psi]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:57:35 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:15:01 2008''