User:Mark Macbeth/Sandbox2: Difference between revisions

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== Background ==

'''Sex Lethal Protein''' (Sxl) is a splicing repressor in the male developmental pathway of [~~https~~://en.wikipedia.org/wiki/Sex-determination_system sex determination] of the common fruit fly, ''[~~https~~://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]''<ref name="Handa">PMID: 10217141</ref>. <scene name='78/783145/Sxl/1'>Sxl</scene> regulates [~~https~~://en.wikipedia.org/wiki/Alternative_splicing alternative splicing] pathways to promote the expression of female sex-linked proteins. In eukaryotes, splicing is carried out via the [https://en.wikipedia.org/wiki/Spliceosome spliceosome], a [~~https~~://en.wikipedia.org/wiki/Ribozyme ribozyme]-protein complex which binds to the 5’ and 3’ splice sites. As Sxl is a splicing repressor, it prevents the binding of the [~~https~~://en.wikipedia.org/wiki/U2AF2 U2AF] and [https://en.wikipedia.org/wiki/U1_spliceosomal_RNA U1 subunits] of the spliceosome at their respective splice sites, which represses the alternative splicing mechanism<ref name="Penalva">PMID: 12966139</ref>. As a result, the fruit fly expressing Sxl will produce mRNA transcripts encoding proteins for the female developmental pathway<ref name="Handa"/>.

'''Sex Lethal Protein''' (Sxl) is a splicing repressor in the male developmental pathway of [http://en.wikipedia.org/wiki/Sex-determination_system sex determination] of the common fruit fly, ''[http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]''<ref name="Handa">PMID: 10217141</ref>. <scene name='78/783145/Sxl/1'>Sxl</scene> regulates [http://en.wikipedia.org/wiki/Alternative_splicing alternative splicing] pathways to promote the expression of female sex-linked proteins. In eukaryotes, splicing is carried out via the [https://en.wikipedia.org/wiki/Spliceosome spliceosome], a [http://en.wikipedia.org/wiki/Ribozyme ribozyme]-protein complex which binds to the 5’ and 3’ splice sites. As Sxl is a splicing repressor, it prevents the binding of the [http://en.wikipedia.org/wiki/U2AF2 U2AF] and [https://en.wikipedia.org/wiki/U1_spliceosomal_RNA U1 subunits] of the spliceosome at their respective splice sites, which represses the alternative splicing mechanism<ref name="Penalva">PMID: 12966139</ref>. As a result, the fruit fly expressing Sxl will produce mRNA transcripts encoding proteins for the female developmental pathway<ref name="Handa"/>.

== Significance ==

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 == Background ==
-'''Sex Lethal Protein''' (Sxl) is a splicing repressor in the male developmental pathway of [https://en.wikipedia.org/wiki/Sex-determination_system sex determination] of the common fruit fly, ''[https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]''<ref name="Handa">PMID: 10217141</ref>. <scene name='78/783145/Sxl/1'>Sxl</scene> regulates [https://en.wikipedia.org/wiki/Alternative_splicing alternative splicing] pathways to promote the expression of female sex-linked proteins. In eukaryotes, splicing is carried out via the [https://en.wikipedia.org/wiki/Spliceosome spliceosome], a [https://en.wikipedia.org/wiki/Ribozyme ribozyme]-protein complex which binds to the 5’ and 3’ splice sites. As Sxl is a splicing repressor, it prevents the binding of the [https://en.wikipedia.org/wiki/U2AF2 U2AF] and [https://en.wikipedia.org/wiki/U1_spliceosomal_RNA U1 subunits] of the spliceosome at their respective splice sites, which represses the alternative splicing mechanism<ref name="Penalva">PMID: 12966139</ref>. As a result, the fruit fly expressing Sxl will produce mRNA transcripts encoding proteins for the female developmental pathway<ref name="Handa"/>.
+'''Sex Lethal Protein''' (Sxl) is a splicing repressor in the male developmental pathway of [http://en.wikipedia.org/wiki/Sex-determination_system sex determination] of the common fruit fly, ''[http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]''<ref name="Handa">PMID: 10217141</ref>. <scene name='78/783145/Sxl/1'>Sxl</scene> regulates [http://en.wikipedia.org/wiki/Alternative_splicing alternative splicing] pathways to promote the expression of female sex-linked proteins. In eukaryotes, splicing is carried out via the [https://en.wikipedia.org/wiki/Spliceosome spliceosome], a [http://en.wikipedia.org/wiki/Ribozyme ribozyme]-protein complex which binds to the 5’ and 3’ splice sites. As Sxl is a splicing repressor, it prevents the binding of the [http://en.wikipedia.org/wiki/U2AF2 U2AF] and [https://en.wikipedia.org/wiki/U1_spliceosomal_RNA U1 subunits] of the spliceosome at their respective splice sites, which represses the alternative splicing mechanism<ref name="Penalva">PMID: 12966139</ref>. As a result, the fruit fly expressing Sxl will produce mRNA transcripts encoding proteins for the female developmental pathway<ref name="Handa"/>.
 == Significance ==