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==The solution structure of the fifth SH3 domain of intersectin 2 (KIAA1256)==
==The solution structure of the fifth SH3 domain of intersectin 2 (KIAA1256)==
<StructureSection load='1udl' size='340' side='right' caption='[[1udl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1udl' size='340' side='right'caption='[[1udl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1udl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UDL FirstGlance]. <br>
<table><tr><td colspan='2'>[[1udl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1UDL FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh15293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh15293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1udl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udl OCA], [http://pdbe.org/1udl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1udl RCSB], [http://www.ebi.ac.uk/pdbsum/1udl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1udl ProSAT], [http://www.topsan.org/Proteins/RSGI/1udl TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1udl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udl OCA], [http://pdbe.org/1udl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1udl RCSB], [http://www.ebi.ac.uk/pdbsum/1udl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1udl ProSAT], [http://www.topsan.org/Proteins/RSGI/1udl TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1udl ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1udl ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Intersectin|Intersectin]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Goroncy, A]]
[[Category: Goroncy, A]]
[[Category: Inoue, M]]
[[Category: Inoue, M]]

Revision as of 10:25, 30 December 2020

The solution structure of the fifth SH3 domain of intersectin 2 (KIAA1256)The solution structure of the fifth SH3 domain of intersectin 2 (KIAA1256)

Structural highlights

1udl is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:KAZUSA cDNA hh15293 (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[ITSN2_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Mettlen M, Stoeber M, Loerke D, Antonescu CN, Danuser G, Schmid SL. Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol Biol Cell. 2009 Jul;20(14):3251-60. doi: 10.1091/mbc.E09-03-0256. Epub 2009, May 20. PMID:19458185 doi:10.1091/mbc.E09-03-0256
  2. ↑ Teckchandani A, Mulkearns EE, Randolph TW, Toida N, Cooper JA. The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis. Mol Biol Cell. 2012 Aug;23(15):2905-16. doi: 10.1091/mbc.E11-12-1007. Epub 2012, May 30. PMID:22648170 doi:10.1091/mbc.E11-12-1007
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