2fp7: Difference between revisions

Revision as of 04:09, 4 May 2008

West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H

OverviewOverview

The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.

About this StructureAbout this Structure

2FP7 is a Protein complex structure of sequences from West nile virus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:16532006 Page seeded by OCA on Sun May 4 04:09:43 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2fp7.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2fp7 |SIZE=350|CAPTION= <scene name='initialview01'>2fp7</scene>, resolution 1.68&Aring;
+The line below this paragraph, containing "STRUCTURE_2fp7", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=NDL:N-BENZOYL-L-NORLEUCYL-L-LYSYL-L-ARGINYL-L-ARGININE'>NDL</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2fp7|  PDB=2fp7  |  SCENE=  }}
-|RELATEDENTRY=[[2fom|2FOM]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp7 OCA], [http://www.ebi.ac.uk/pdbsum/2fp7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fp7 RCSB]</span>
-}}
 '''West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H'''
@@ Line 29: / Line 26: @@
 [[Category: Erbel, P.]]
 [[Category: Schiering, N.]]
-[[Category: flavivirus]]
+[[Category: Flavivirus]]
-[[Category: ns2b cofactor]]
+[[Category: Ns2b cofactor]]
-[[Category: ns3 protease]]
+[[Category: Ns3 protease]]
-[[Category: substrate-based inhibitor]]
+[[Category: Substrate-based inhibitor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:09:43 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:05:54 2008''