6fvi: Difference between revisions

Latest revision as of 10:52, 20 March 2019

ASH / PapD-like domain of human CEP192 (PapD-like domain 7)ASH / PapD-like domain of human CEP192 (PapD-like domain 7)

Structural highlights

6fvi is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CE192_HUMAN] Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804).^[1] ^[2] ^[3]

References

↑ Gomez-Ferreria MA, Rath U, Buster DW, Chanda SK, Caldwell JS, Rines DR, Sharp DJ. Human Cep192 is required for mitotic centrosome and spindle assembly. Curr Biol. 2007 Nov 20;17(22):1960-6. doi: 10.1016/j.cub.2007.10.019. Epub 2007, Nov 1. PMID:17980596 doi:http://dx.doi.org/10.1016/j.cub.2007.10.019
↑ Zhu F, Lawo S, Bird A, Pinchev D, Ralph A, Richter C, Muller-Reichert T, Kittler R, Hyman AA, Pelletier L. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Curr Biol. 2008 Jan 22;18(2):136-41. doi: 10.1016/j.cub.2007.12.055. PMID:18207742 doi:http://dx.doi.org/10.1016/j.cub.2007.12.055
↑ Joukov V, Walter JC, De Nicolo A. The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly. Mol Cell. 2014 Aug 21;55(4):578-91. doi: 10.1016/j.molcel.2014.06.016. Epub 2014 , Jul 17. PMID:25042804 doi:http://dx.doi.org/10.1016/j.molcel.2014.06.016

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OCA

[1] Gomez-Ferreria MA, Rath U, Buster DW, Chanda SK, Caldwell JS, Rines DR, Sharp DJ. Human Cep192 is required for mitotic centrosome and spindle assembly. Curr Biol. 2007 Nov 20;17(22):1960-6. doi: 10.1016/j.cub.2007.10.019. Epub 2007, Nov 1. PMID:17980596 doi:http://dx.doi.org/10.1016/j.cub.2007.10.019

[2] Zhu F, Lawo S, Bird A, Pinchev D, Ralph A, Richter C, Muller-Reichert T, Kittler R, Hyman AA, Pelletier L. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Curr Biol. 2008 Jan 22;18(2):136-41. doi: 10.1016/j.cub.2007.12.055. PMID:18207742 doi:http://dx.doi.org/10.1016/j.cub.2007.12.055

[3] Joukov V, Walter JC, De Nicolo A. The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly. Mol Cell. 2014 Aug 21;55(4):578-91. doi: 10.1016/j.molcel.2014.06.016. Epub 2014 , Jul 17. PMID:25042804 doi:http://dx.doi.org/10.1016/j.molcel.2014.06.016

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6fvi is ON HOLD  until Paper Publication
+==ASH / PapD-like domain of human CEP192 (PapD-like domain 7)==
+<StructureSection load='6fvi' size='340' side='right'caption='[[6fvi]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6fvi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FVI FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fvi OCA], [http://pdbe.org/6fvi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fvi RCSB], [http://www.ebi.ac.uk/pdbsum/6fvi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fvi ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CE192_HUMAN CE192_HUMAN]] Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804).<ref>PMID:17980596</ref> <ref>PMID:18207742</ref> <ref>PMID:25042804</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Breugel, M van]]
+[[Category: Kovalevskiy, O V]]
+[[Category: Ash domain]]
+[[Category: Cell cycle]]
+[[Category: Centriole]]
+[[Category: Centrosome]]
+[[Category: Papd-like domain]]

6fvi: Difference between revisions

Latest revision as of 10:52, 20 March 2019

ASH / PapD-like domain of human CEP192 (PapD-like domain 7)ASH / PapD-like domain of human CEP192 (PapD-like domain 7)

Structural highlights

Function

References

Contents

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6fvi: Difference between revisions

Latest revision as of 10:52, 20 March 2019

ASH / PapD-like domain of human CEP192 (PapD-like domain 7)ASH / PapD-like domain of human CEP192 (PapD-like domain 7)

Structural highlights

Function

References

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