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{{STRUCTURE_2fkk| PDB=2fkk | SCENE= }} | |||
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'''Crystal structure of the C-terminal domain of the bacteriophage T4 gene product 10''' | '''Crystal structure of the C-terminal domain of the bacteriophage T4 gene product 10''' | ||
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[[Category: Rossmann, M G.]] | [[Category: Rossmann, M G.]] | ||
[[Category: Shneider, M M.]] | [[Category: Shneider, M M.]] | ||
[[Category: | [[Category: Bacteriophage t4]] | ||
[[Category: | [[Category: Baseplate]] | ||
[[Category: | [[Category: Evolution]] | ||
[[Category: | [[Category: Gp10]] | ||
[[Category: | [[Category: Structural comparison]] | ||
[[Category: | [[Category: Tail]] | ||
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Revision as of 04:00, 4 May 2008
Crystal structure of the C-terminal domain of the bacteriophage T4 gene product 10
OverviewOverview
The success of tailed bacteriophages to infect cells far exceeds that of most other viruses on account of their specialized tail and associated baseplate structures. The baseplate protein gene product (gp) 10 of bacteriophage T4, whose structure was determined to 1.2 A resolution, was fitted into the cryo-electron microscopy structures of the pre and post-infection conformations of the virus. gp10 functions as a molecular lever that rotates and extends the hinged short tail fibers to facilitate cell attachment. The central folding motif of the gp10 trimer is similar to that of the baseplate protein gp11 and to the receptor-binding domain of the short tail fiber, gp12. The three proteins comprise the periphery of the baseplate and interact with each other. The structural and functional similarities of gp10, gp11, and gp12 and their sequential order in the T4 genome suggest that they evolved separately, subsequent to gene triplication from a common ancestor. Such events are usual in the evolution of complex organelles from a common primordial molecule.
About this StructureAbout this Structure
2FKK is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.
ReferenceReference
Evolution of bacteriophage tails: Structure of T4 gene product 10., Leiman PG, Shneider MM, Mesyanzhinov VV, Rossmann MG, J Mol Biol. 2006 May 5;358(3):912-21. Epub 2006 Mar 9. PMID:16554069 Page seeded by OCA on Sun May 4 04:00:19 2008