Alice Clark/ATPsynthase: Difference between revisions
Alice Clark (talk | contribs) No edit summary |
Alice Clark (talk | contribs) No edit summary |
||
| Line 12: | Line 12: | ||
'' | ''Tools for exploring ATP synthase in 3D'' | ||
- left mouse button to rotate the protein model. | - left mouse button to rotate the protein model. | ||
| Line 19: | Line 19: | ||
- right mouse button for more options and information (control-click on a Mac). | - right mouse button for more options and information (control-click on a Mac). | ||
- green text - click to load a new 3D scene | |||
'''Have a go yourself now ==>''' | '''Have a go yourself now ==>''' | ||
| Line 33: | Line 35: | ||
---- | ---- | ||
The F1 binds the adenosine diphosphate (ADP) molecules and the adenosine triphosphate (ATP) <scene name='78/781973/Atpandadp/1'>binding sites</scene>. See if you can zoom in on the ATP identify the phosphate atoms (orange). | The F1 binds the adenosine diphosphate (ADP) molecules and the adenosine triphosphate (ATP) <scene name='78/781973/Atpandadp/1'>binding sites</scene>. See if you can zoom in on the ATP identify the phosphate atoms (orange). | ||
---- | ---- | ||
''' | '''Q2: How many phosphates does ATP have, and how does this differ to ADP?''' | ||
---- | ---- | ||
''' | '''Q3: Where is the high energy bond that the ATP synthase forms''' | ||
---- | ---- | ||
The <scene name='78/781973/Axel/1'>axle</scene> rotates putting the motor into three different conformations as the ADP binds, the phosphate bond is formed and the ATP being released. | The <scene name='78/781973/Axel/1'>axle</scene> rotates putting the motor into three different conformations as the ADP binds, the phosphate bond is formed and the ATP being released. | ||
---- | ---- | ||
''' | '''Q4: What is the role of the axel?''' | ||
---- | ---- | ||
<scene name='78/781973/F0/1'>The F0</scene> is a circular rotor that is formed of alpha helices that sit in the mitochondrial membrane. The hydrogen ions travel around the circular F0 motor, and turning the rotor in the process, much like a water wheel. The hydrogens are passed alone a chain of <scene name='78/781973/Aspgluchain/1'>aspartic acid residues or glutamic acid</scene> (amino acids) in the F0 motor, and then transferred to an <scene name='78/781973/Arg/1'>arginine</scene> (Arg) amino acid. The arginine passes the hydrogen to the rotor, which turns all the way around. Then the hydrogen is then passed to the opposite side of the membrane. | <scene name='78/781973/F0/1'>The F0</scene> is a circular rotor that is formed of alpha helices that sit in the mitochondrial membrane. The hydrogen ions travel around the circular F0 motor, and turning the rotor in the process, much like a water wheel. The hydrogens are passed alone a chain of <scene name='78/781973/Aspgluchain/1'>aspartic acid residues or glutamic acid</scene> (amino acids) in the F0 motor, and then transferred to an <scene name='78/781973/Arg/1'>arginine</scene> (Arg) amino acid. The arginine passes the hydrogen to the rotor, which turns all the way around. Then the hydrogen is then passed to the opposite side of the membrane. | ||
---- | ---- | ||
''' | '''Q5: What is the location and role of the FO region?''' | ||
---- | ---- | ||
''' | '''Q6: Name two key amino acids, one acidic and one basic, that bind the hydrogen's in the ATP generation?''' | ||
---- | ---- | ||