Alice Clark/ATPsynthase: Difference between revisions
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== '''ATP Synthase''' == | |||
<StructureSection load='5lqz' size='350' side='right' caption='ATP Synthase (PDB entry [[5lqz]])' scene=''> | |||
The synthesis of ATP involves a number of steps | |||
1. Binding of ADP and the phosphate | |||
2. Formation of the new high energy phosphate-phosphate bond | |||
3. Releasing the newly made ATP | |||
These steps are performed by a tiny motor, found in the mitochondrial membrane, called ATP synthase | |||
'''The ATP synthase molecule is built up of different proteins each with a seperate role ''' | |||
< | The F1 motor contains <scene name='78/781973/F1_alpha/1'>alpha</scene> and <scene name='78/781973/F1_beta/1'>beta</scene> chains. It also has the adenosine diphosphate (ADP) molecules and the adenosine triphosphate ATP <scene name='78/781973/Atpandadp/1'>binding sites</scene>. See if you can zoom in on the ATP identify the base, sugar and phosphates that make up these molecules. | ||
''' | ---- | ||
'''Q1: Where is the F1 region located within the ATP synthase, and what is its role?''' | |||
---- | |||
The | The axle rotates putting the motor into three different conformations as the ADP binds, the phosphate bond is formed and the ATP being released. | ||
stator | stator | ||
The F0 is formed of membrane | The F0 is a circular rotor that is formed of alpha helices that sit in the mitochondrial membrane. The hydrogen ions travel around the circular F0 motor, and turning the rotor in the process, much like a water wheel. The hydrogens are passed alone a chain of aspartic acid residues (amino acids) in the F0 motor, and then transferred to an arginine amino acid. The arginine passes the hydrogen to the rotor, which turns all the way around. Then the hydrogen is then passed to the opposite side of the membrane. | ||
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Key Terms | |||
Aspartic acid | |||
ATP | |||
AMP | |||
ATP synthase | |||
</StructureSection> | </StructureSection> | ||
Revision as of 15:05, 10 March 2018
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ATP SynthaseATP Synthase
The synthesis of ATP involves a number of steps 1. Binding of ADP and the phosphate 2. Formation of the new high energy phosphate-phosphate bond 3. Releasing the newly made ATP These steps are performed by a tiny motor, found in the mitochondrial membrane, called ATP synthase
The ATP synthase molecule is built up of different proteins each with a seperate role The F1 motor contains and chains. It also has the adenosine diphosphate (ADP) molecules and the adenosine triphosphate ATP . See if you can zoom in on the ATP identify the base, sugar and phosphates that make up these molecules. Q1: Where is the F1 region located within the ATP synthase, and what is its role? The axle rotates putting the motor into three different conformations as the ADP binds, the phosphate bond is formed and the ATP being released.
stator The F0 is a circular rotor that is formed of alpha helices that sit in the mitochondrial membrane. The hydrogen ions travel around the circular F0 motor, and turning the rotor in the process, much like a water wheel. The hydrogens are passed alone a chain of aspartic acid residues (amino acids) in the F0 motor, and then transferred to an arginine amino acid. The arginine passes the hydrogen to the rotor, which turns all the way around. Then the hydrogen is then passed to the opposite side of the membrane.
To the right is a structure of ATP synthase shown using the Jmol viewer within Proteopedia.
Exploring in 3D - left mouse button to rotate the protein model. - middle mouse button or scroll wheel to zoom (option-click on a Mac) - right mouse button for more options and information (control-click on a Mac). Have a go yourself now ==>
Click '>here</scene> for a view where the different components are coloured differently? See how many you can identify
Q2: How many ATP can you find? Q3: What is the location and role of the FO region?
ATP synthase is an example of a molecular motor. Use the Structure to answer the questions below. Q4: How many phosphates does ATP have? Q5: How many phosphates does ADP have
Key Terms Aspartic acid ATP AMP ATP synthase
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