2ffh: Difference between revisions

Revision as of 03:49, 4 May 2008

THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS

OverviewOverview

The crystal structure of the signal sequence binding subunit of the signal recognition particle (SRP) from Thermus aquaticus reveals a deep groove bounded by a flexible loop and lined with side chains of conserved hydrophobic residues. The groove defines a flexible, hydrophobic environment that is likely to contribute to the structural plasticity necessary for SRP to bind signal sequences of different lengths and amino acid sequence. The structure also reveals a helix-turn-helix motif containing an arginine-rich alpha helix that is required for binding to SRP RNA and is implicated in forming the core of an extended RNA binding surface.

About this StructureAbout this Structure

2FFH is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the signal sequence binding subunit of the signal recognition particle., Keenan RJ, Freymann DM, Walter P, Stroud RM, Cell. 1998 Jul 24;94(2):181-91. PMID:9695947 Page seeded by OCA on Sun May 4 03:49:56 2008

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OCA

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 [[Image:2ffh.gif|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_2ffh", creates the "Structure Box" on the page.
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+You may change the PDB parameter (which sets the PDB file loaded into the applet)
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-|RELATEDENTRY=[[1ffh|1FFH]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffh OCA], [http://www.ebi.ac.uk/pdbsum/2ffh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ffh RCSB]</span>
-}}
 '''THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS'''
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 [[Category: Stroud, R M.]]
 [[Category: Walter, P.]]
-[[Category: ffh]]
+[[Category: Ffh]]
-[[Category: gtpase]]
+[[Category: Gtpase]]
-[[Category: helix-turn-helix]]
+[[Category: Helix-turn-helix]]
-[[Category: m domain]]
+[[Category: M domain]]
-[[Category: protein targeting]]
+[[Category: Protein targeting]]
-[[Category: rna-binding]]
+[[Category: Rna-binding]]
-[[Category: signal recognition particle]]
+[[Category: Signal recognition particle]]
-[[Category: signal sequence-binding]]
+[[Category: Signal sequence-binding]]
-[[Category: srp54]]
+[[Category: Srp54]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:49:56 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:02:07 2008''