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==X-ray structure of the H235Q mutant of GLIC in complex with propofol== | ==X-ray structure of the H235Q mutant of GLIC in complex with propofol== | ||
<StructureSection load='5mzr' size='340' side='right' caption='[[5mzr]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='5mzr' size='340' side='right'caption='[[5mzr]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5mzr]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZR FirstGlance]. <br> | <table><tr><td colspan='2'>[[5mzr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZR FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PFL:2,6-BIS(1-METHYLETHYL)PHENOL'>PFL</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PFL:2,6-BIS(1-METHYLETHYL)PHENOL'>PFL</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=251221 GLOVI])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzr OCA], [http://pdbe.org/5mzr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzr RCSB], [http://www.ebi.ac.uk/pdbsum/5mzr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzr ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzr OCA], [http://pdbe.org/5mzr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzr RCSB], [http://www.ebi.ac.uk/pdbsum/5mzr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | [[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | ||
==See Also== | |||
*[[Ion channels 3D structures|Ion channels 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Glovi]] | |||
[[Category: Large Structures]] | |||
[[Category: Delarue, M]] | [[Category: Delarue, M]] | ||
[[Category: Fourati, Z]] | [[Category: Fourati, Z]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 09:41, 16 October 2019
X-ray structure of the H235Q mutant of GLIC in complex with propofolX-ray structure of the H235Q mutant of GLIC in complex with propofol
Structural highlights
Function[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1] See AlsoReferences
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