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'''Eukaryotic translation initiation factor 5A from Methanococcus jannaschii''' | '''Eukaryotic translation initiation factor 5A from Methanococcus jannaschii''' | ||
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[[Category: Kim, R.]] | [[Category: Kim, R.]] | ||
[[Category: Kim, S H.]] | [[Category: Kim, S H.]] | ||
[[Category: | [[Category: Berkeley structural genomics center]] | ||
[[Category: | [[Category: Bsgc structure funded by nih]] | ||
[[Category: | [[Category: Eif-5a]] | ||
[[Category: | [[Category: Ob-fold]] | ||
[[Category: | [[Category: Protein structure initiative]] | ||
[[Category: | [[Category: Psi]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: | [[Category: Translation]] | ||
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Revision as of 02:35, 4 May 2008
Eukaryotic translation initiation factor 5A from Methanococcus jannaschii
OverviewOverview
Eukaryotic translation initiation factor 5A (eIF-5A) is a ubiquitous protein found in all eukaryotic cells. The protein is closely associated with cell proliferation in the G1-S stage of the cell cycle. Recent findings show that the eIF-5A proteins are highly expressed in tumor cells and act as a cofactor of the Rev protein in HIV-1-infected cells. The mature eIF is the only protein known to have the unusual amino acid hypusine, a post-translationally modified lysine. The crystal structure of eIF-5A from Methanococcus jannaschii (MJ eIF-5A) has been determined at 1.9 A and 1.8 A resolution in two crystal forms by using the multiple isomorphous replacement method and the multiwavelength anomalous diffraction method for the first crystal form and the molecular replacement method for the second crystal form. The structure consists of two folding domains, one of which is similar to the oligonucleotide-binding domain found in the prokaryotic cold shock protein and the translation initiation factor IF1 despite the absence of any significant sequence similarities. The 12 highly conserved amino acid residues found among eIF-5As include the hypusine site and form a long protruding loop at one end of the elongated molecule.
About this StructureAbout this Structure
2EIF is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures of eukaryotic translation initiation factor 5A from Methanococcus jannaschii at 1.8 A resolution., Kim KK, Hung LW, Yokota H, Kim R, Kim SH, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10419-24. PMID:9724718 Page seeded by OCA on Sun May 4 02:35:50 2008