4qbe: Difference between revisions

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 ==The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop==
-<StructureSection load='4qbe' size='340' side='right' caption='[[4qbe]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
+<StructureSection load='4qbe' size='340' side='right'caption='[[4qbe]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4qbe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QBE FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4qbe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QBE FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qah|4qah]], [[4qap|4qap]], [[4qbw|4qbw]]</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbe OCA], [https://pdbe.org/4qbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qbe RCSB], [https://www.ebi.ac.uk/pdbsum/4qbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qbe ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbe OCA], [http://pdbe.org/4qbe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qbe RCSB], [http://www.ebi.ac.uk/pdbsum/4qbe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qbe ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
+[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 17: @@
 </div>
 <div class="pdbe-citations 4qbe" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Large Structures]]
-[[Category: Bi, W X]]
+[[Category: Bi WX]]
-[[Category: Cui, F A]]
+[[Category: Cui FA]]
-[[Category: Fu, X L]]
+[[Category: Fu XL]]
-[[Category: Wang, H M]]
+[[Category: Wang HM]]
-[[Category: Wang, X]]
+[[Category: Wang X]]
-[[Category: Xiao, P]]
+[[Category: Xiao P]]
-[[Category: Yu, X]]
+[[Category: Yu X]]
-[[Category: Classic ptyr-specific ptp]]
-[[Category: Hydrolase]]
-[[Category: Tyrosine phosphorylation]]