6c1t: Difference between revisions

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-'''Unreleased structure'''
-The entry 6c1t is ON HOLD  until Feb 14 2019
+==MBD2 in complex with a partially methylated DNA==
+<StructureSection load='6c1t' size='340' side='right' caption='[[6c1t]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
-Authors: Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6c1t]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C1T FirstGlance]. <br>
-Description: MBD2 in complex with a partially methylated DNA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c1t OCA], [http://pdbe.org/6c1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c1t RCSB], [http://www.ebi.ac.uk/pdbsum/6c1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c1t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MBD2_HUMAN MBD2_HUMAN]] Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.<ref>PMID:10471499</ref> <ref>PMID:10947852</ref> <ref>PMID:12665568</ref> <ref>PMID:16415179</ref> <ref>PMID:24307175</ref> <ref>PMID:9774669</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Edwards, A M]]
+[[Category: Lei, M]]
 [[Category: Min, J]]
-[[Category: Edwards, A.M]]
+[[Category: Structural genomic]]
-[[Category: Arrowsmith, C.H]]
-[[Category: Structural Genomics Consortium (Sgc)]]
-[[Category: Lei, M]]
-[[Category: Bountra, C]]
 [[Category: Tempel, W]]
+[[Category: Dna binding protein-dna complex]]
+[[Category: Dna-binding]]
+[[Category: Mbd]]
+[[Category: Sgc]]