VprBP: Difference between revisions

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== Structural highlights ==
== Structural highlights ==


The interactions between VprBP and Vpr are located in a cleft formed by <scene name='77/776391/Cv/3'>VprBD canonical WD40 seven-blade β-propeller</scene> which is lined by acidic residues on one end and hydrophobic residues at the center.  The interactions are formed by hydrogen bonds, Vpr Phe residue buried in VprBP hydrophobic pocket and VprBP Trp binding to residues in Vpr pocket<ref>PMID:27571178</ref>.
The interactions between VprBP and Vpr are located in a cleft formed by <scene name='77/776391/Cv/3'>VprBD canonical WD40 seven-blade β-propeller</scene> ({{Template:ColorKey_Helix}}, {{Template:ColorKey_Strand}}, {{Template:ColorKey_Loop}}, {{Template:ColorKey_Turn}}) which is <scene name='77/776391/Cv/4'>lined by acidic residues on one end and hydrophobic residues at the center</scene> ({{Template:ColorKey_Charge_Anionic}} / {{Template:ColorKey_Charge_Cationic}}; {{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}).  The interactions are formed by hydrogen bonds, Vpr Phe residue buried in VprBP hydrophobic pocket and VprBP Trp binding to residues in Vpr pocket<ref>PMID:27571178</ref>.
</StructureSection>
</StructureSection>
== 3D Structures of VprBP ==
== 3D Structures of VprBP ==

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Michal Harel, Jaime Prilusky, Alexander Berchansky